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Heme oxygenase-1 ferroptosis

Web10 jan. 2024 · Proteomics research and molecular biology experiments reveal that iCoDMSN is a potent ferroptosis inducer in cancer cells. Mechanistically, iCoDMSNs … Web10 apr. 2024 · These extracts administered to mice also inhibited ferroptosis in the liver by regulating the expression of Acyl-CoA synthetase long chain family member 4 (ACSL4), …

The effects of Korean red ginseng on heme oxygenase-1 with a …

Web15 sep. 2015 · The heme oxygenase (HO) is a major intracellular source of iron. In this study, the role of heme oxygenase in Erastin-triggered ferroptotic cancer cell death has … Web10 apr. 2024 · Hepatic fibrosis is a complication of liver injury and a common pathological result of long-term hepatic inflammation due to viral hepatitis, alcohol abuse, obesity-related nonalcoholic steatohepatitis (NASH) and autoimmune hepatitis lacking effective intervention. Untreated hepatic fibrosis will eventually progress into cirrhosis [ 4, 5, 6 ]. technology 1966 https://maskitas.net

A Dual Role of Heme Oxygenase-1 in Cancer Cells - ResearchGate

Web8 apr. 2024 · 1.Introduction. Korean Red ginseng (KRG) (Panax ginseng C.A. Meyer) contains a mixture of saponin monomers and ginsenosides [1].KRG has been … Web1 jul. 2024 · Among them, heme oxygenase-1 (HMOX1, also known as HO-1) and solute carrier family 7 member 11 (SLC7A11) were identified as the most dramatically … Web24 mrt. 2024 · Ferroptosis is a modality of regulated cell death, and previous studies have found that inducing ferroptosis in liver cancer cells can inhibit the progression of liver cancer. The aim of this study is to investigate the regulatory mechanism of miR-21-5p in regulating ferroptosis in HCC cells. Methods technology 2007

Excess heme upregulates heme oxygenase 1 and promotes cardiac ...

Category:Cardiac ferroptosis: new jigsaw in SCD puzzles Blood American ...

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Heme oxygenase-1 ferroptosis

Heme oxygenase-1 modulates ferroptosis by fine-tuning levels of ...

Web3 mei 2024 · Heme oxygenase (HO) has both beneficial and detrimental effects via its metabolites, including carbon monoxide (CO), biliverdin or bilirubin, and ferrous iron. HO … Web21 feb. 2024 · Keywords: cyclophosphamide, ferroptosis, heme oxygenase-1, nuclear factor E2 related factor 2, RNA sequencing. Citation: Shi H, Hou B, Li H, Zhou H and Du …

Heme oxygenase-1 ferroptosis

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WebSubsequently, both in vitro and in vivo results confirmed that QCT activated the NFE2-related factor 2 (Nrf2)/Heme oxygenase-1(HO-1) signaling pathway by increasing the levels of Nrf2 and HO-1. Therefore, this study supports that QCT inhibits the ferroptosis of renal tubular epithelial cells by regulating the Nrf2/HO-1 signaling pathway, providing a novel … WebHeme oxygenase-1-induced ferroptosis can cause renal tubular injury in db/db mice by degrading heme to accumulate iron [Citation 8]. Knockdown of salusin-β inhibited high …

WebIschemia-reperfusion (I/R) injury is a major challenge in perioperative medicine that contributes to pathological damage in various conditions, including ischemic stroke, myocardial infarction, acute lung injury, liver transplantation, acute kidney injury and hemorrhagic shock. I/R damage is often irreversible, and current treatments for I/R injury … WebThe heme oxygenase (HO) is a major intracellular source of iron. In this study, the role of heme oxygenase in Erastin-triggered ferroptotic cancer cell death has been investigated.

Web23 sep. 2024 · Heme oxygenase-1 modulates ferroptosis by fine-tuning levels of intracellular iron and reactive oxygen species of macrophages in response to Bacillus … Web2 sep. 2015 · In support of HO-1 promoting ferroptosis, its inhibition by ZnPP protected human HT-1080 fibrosarcoma cells from the system X c − inhibitor 18. 193 Silencing of …

Web10 feb. 2024 · Although Hmox1 was thought to be a protective antioxidant enzyme, recent studies have demonstrated its role in promoting iron overload in β-thalassemia5 and …

Web23 jan. 2024 · Heme oxygenase-1 (HO-1) is a cytopro- tective enzyme induced in response to cellular stress, and is protective against AKI because of its antiapoptotic and anti … spcct3.2Web8 apr. 2024 · Heme oxygenase (HO) (i.e., HO-1 and HO-2) is an essential enzyme in heme catabolism that cleaves heme to produce carbon monoxide (CO), biliverdin (which is rapidly converted to bilirubin), and ferrous iron (Fe 2+ ); oxygen … spcc t 2Web10 feb. 2024 · Although Hmox1 was thought to be a protective antioxidant enzyme, recent studies have demonstrated its role in promoting iron overload in β-thalassemia 5 and … technology 2011