WebDanazol is a derivative of the synthetic steroid ethisterone, that suppresses the production of gonadotrophins, and has some weak androgenic effects. ... 5.8E-008 mm Hg (25 deg … WebJun 1, 2024 · Danazol is a synthetic steroid (Fig. 1), which is used for the treatment of a range of conditions, such as endometriosis and myelofibrosis. 16 Danazol is a non-ionizable compound, with a high logP of 4.53, and a very low aqueous solubility of 0.6–0.9 μg/ml. 17, 18 Danazol is a class II compound according to the biopharmaceutics ...
Surface treatment of the hydrophobic drug danazol to improve …
WebAqueous danazol solutions formed a drug-rich phase with a mean size of 250 nm when the concentration exceeded the amorphous solubility, and the polymers modified the … WebDanazol was selected as a model drug as it is a Biopharmaceutical Classification System Class II compound whose oral bioavailability is limited by low dissolution velocity and water solubility (<0.001 mg/ml, logP = 4.53).[23,24] Danazol has a C max and T max of 53.2 ng/ml and 2.5 h, respectively, after administering a single dose of 200 mg. The ... property taxes lauderdale county al
Formulation and Performance of Danazol Nano-crystalline
WebAug 1, 2000 · The model poorly-water soluble drugs we chose to study were fenofibrate and danazol, which are class-II compounds, according to the Biopharmaceutical … WebAug 1, 2000 · The model poorly-water soluble drugs we chose to study were fenofibrate and danazol, which are class-II compounds, according to the Biopharmaceutical classification system (BCS), and thus have... Web720 rows · Summary Danazol is a synthetic steroid and pituitary gonadotropin inhibitor … property taxes la county