Cisplatin sensitivity
WebFinally, an autophagy assay followed by western blotting was performed to study the effects of co-knockdown genes on cell autophagy in the presence and absence of cisplatin. … WebApr 1, 2024 · Abstract. NKX2-1 was shown to enhance cisplatin sensitivity in KRAS-mutated cells, but it conferred cisplatin resistance in EGFR-mutated lung adenocarcinoma …
Cisplatin sensitivity
Did you know?
WebJun 24, 2011 · ICL-based chemotherapy is one of the most widely used forms of cancer treatment, particularly in the treatment of leukaemias. Fanconi anaemia (FA) is a disorder that results in sensitivity to... WebDec 9, 2024 · By analysing RNA-seq data in OSCC cells treated with vitamin D and cisplatin, we found that lipocalin 2 (LCN2) was an important modulator of cisplatin …
WebFeb 7, 2024 · The cytotoxicity of cisplatin was evaluated in six bladder cancer cell lines to compare their responses to cisplatin. The T24 cancer cells exhibited the lowest sensitivity to cisplatin and was therefore selected to explore the mechanisms of drug resistance. Web2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need …
WebWorldwide, the number of cancer-related deaths continues to increase due to the ability of cancer cells to become chemotherapy-resistant and metastasize. For women with … WebMay 14, 2024 · Cisplatin is a highly effective chemotherapy regimen for individuals with BCa. However, cisplatin-based chemotherapy would be effective in less than 50% of BCa patients (Sagalowsky 2013 ). Cell-cycle regulation is one of the major determinants of cisplatin chemosensitivity (Yang et al. 2024; Borst et al. 2014 ).
WebJul 22, 2024 · Figure 1 Olaparib and cisplatin (CDDP) in vitro sensitivities are not influenced by the BRCA1 status of TNBC cells. (A) MTT assays of MDA-MB-468, SUM1315, MDA-MB-231 and HCC1937 cells. Data are mean ± S.D. of three independent experiments. (B) Isobologram analysis of the combination of olaparib and CDDP in constant 1:1 ratio.
WebNov 12, 2024 · Commonly reported side effects of cisplatin include: bone marrow depression, nephrotoxicity, and ototoxicity. Continue reading for a comprehensive list of … lit coffre malm 160x200 ikeaWebMar 15, 2003 · Cisplatin-resistance cell lines CP70, C30, and C200 were produced by intermittent, incremental exposure of the sensitive parental A2780 cell line to various concentrations of cisplatin. OVCAR-4 and OVCAR-10 cell lines were developed from patients who were clinically refractory to platinum-based chemotherapy (16, 17). lit coffre dreameaWebMar 15, 2024 · The results indicated that URI knockdown increased the sensitivity of cells to cisplatin by inhibiting proliferation and promoting apoptosis. The levels of P-ATM, P-CHK2 and γH2AX were detected by Western blot. Increased levels of P-ATM, P-CHK2, and γH2AX were observed in cisplatin treated cells, indicating that cisplatin induced a DNA … imperial park newport walesWebNov 15, 1987 · Two sublines were derived from a human bladder carcinoma continuous cell line (RT112-P), one by exposure to fractionated X-irradiation (RT112-DXR8) and the … imperial park rayleighWebOct 7, 2002 · Work from many laboratories has implicated DNA as a critical target for cisplatin cytotoxicity, the most revealing evidence being the hypersensitivity to cisplatin of both prokaryotic and eukaryotic cells deficient in DNA repair ( 3–5 ). imperial paris hotelWeb2 days ago · Blockade of neddylation increases cisplatin sensitivity of testicular germ cell tumors. In turn, inhibition of the neddylation cascade leads to an accumulation of suppressor proteins and ... imperial parking systems nycWebFor the first time, our study implies that d-borneol enhanced cisplatin sensitivity by inducing ferroptosis, promoting autophagy and inhibiting EMT progression, thereby … imperial park recreation center iprc