Cisplatin research

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August undefined, 2024

WebCisplatin is a potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF- α -induced apoptosis. Technical Data M.Wt: 300.05 Formula: WebSep 18, 2024 · Cisplatin is a medication used to manage and treat solid tumors and hematologic malignancies. It is in the alkylating agent class of cytotoxic medications. This activity reviews the indications, action, and …

Gene scissors find target for testicular cancer therapy

Web2 days ago · Overactive gene NAE1 lifts the cell division brake. To get to the bottom of the causes of cisplatin resistance in testicular cancer, the Bonn research team used … WebResearch Day 2024. Serum platinum levels and cisplatin induced ototoxicity among pediatric germ cell tumor survivors. Lacy Pehlke. MPH, Epidemiology. Co-Authors: Jen … chitchat crossword puzzle clue

Exploring the Metabolic Differences between Cisplatin

Webcisplatin It is a treatment for a number of different types of cancer. How GC works These chemotherapy drugs destroy quickly dividing cells, such as cancer cells. How you have GC You have these drugs into your bloodstream (intravenously). You might have treatment through a long plastic tube that goes into a large vein in your chest. WebMost sources say that cisplatin is soluble in water and saline at around 1 mg/ml - 2.5 mg/ml depending on the source. I saw in the attached article (under liposome preparation method) that they ... WebFantastic. These were the words that kept coming up during the 40th Anniversary Cisplatin Celebration and Cancer Research Symposium, held Aug. 3-4 on the Michigan State University campus. The event marked the 40th anniversary of the FDA’s 1978 approval of the anti-cancer drug cisplatin. It was in the mid-1960s that MSU biophysicist Barnett ... chit chat cosmetics

Serum platinum levels and cisplatin induced ototoxicity among …

Molecules Free Full-Text The Challenging Treatment of …

WebJun 13, 2005 · Cisplatin, cisplatinum or cis-diamminedichloroplatinum (II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes … WebSep 24, 2024 · Cisplatin is a highly effective chemotherapeutic agent used to treat various cancers. Patients are administered controlled doses of cisplatin intravenously as an infusion. Even though cisplatin is very effective at its job, it has its own toxic side effects. chitchat coffee \u0026 matchaWeb2 days ago · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative … chitchat dataset

"WebCisplatin, a class of platinum-containing anticancer drugs for the treatment of solid tumors, is a substrate of OCT2 and MATE1/MATE2-K. OCT2 is expressed in the basolateral … " - Cisplatin research

Cisplatin research

Concurrent cisplatin, infusional fluorouracil, and conventionally ...

WebCisplatin is a chemotherapeutic drug that has been used in the treatment of various types of human cancers such as ovarian, lung, head and neck, testicular and bladder. Cisplatin has demonstrated efficacy against various types of cancers such as germ cell tumors, sarcomas, carcinomas as well as lymphomas. WebCisplatin is a chemotherapy drug. You might have it as a treatment for a number of different types of cancer. You might have cisplatin on its own or in combination with other cancer …

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WebMay 1, 2006 · Abstract and Figures Cisplatin is currently one of the most widely used anticancer drugs in the world. The unlikely events surrounding the discovery of its anticancer activity, subsequent... WebChemical Name. cis-Diaminodichloroplatinum. Biological Activity. Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent …

WebJan 18, 2024 · CX is the name of a combination of chemotherapy drugs; cisplatin and capecitabine. It is a treatment for a number of different types of cancer. ... Cancer Research UK is a registered charity in England and Wales (1089464), Scotland (SC041666), the Isle of Man (1103) and Jersey (247). A company limited by guarantee. … WebCisplatin is in a class of medications known as platinum-containing compounds. It works by stopping or slowing the growth of cancer cells. How should this medicine be used? Cisplatin injection comes as a solution (liquid) to be injected over 6 to 8 hours intravenously (into a vein) by a doctor or nurse in a medical facility.

WebSep 23, 2016 · The subsequent intracellular signaling pathway analysis indicated that pAkt and p62 expression levels correlated with alterations in the IC50 values for cisplatin in ovarian cancer, providing an... WebCisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and other similar …

WebThe researchers found that when they applied an electric current through platinum electrodes in a continuous culture chamber containing E. coli bacteria, a reaction occurred in which the supposedly inert platinum metal (Pt 0) of the electrodes was oxidized to form both platinum (II) (Pt 2+) and platinum (IV) (Pt 4+ ).

WebMar 15, 2003 · Abstract. Ovarian cancer is the leading cause of death among women from gynecological malignancies inthe United States. Resistance to the chemotherapeutic agent cisplatin isa major limitation for the successful treatment of ovarian cancer. In an effort to overcome the cisplatin resistance problem in ovarian cancer treatment, we have sought … graph with filter excelWebMay 1, 2005 · Cisplatin is a chemotherapeutic drug used in conjunction with IR to treat various types of cancer, including cervical carcinoma as well as head and neck cancers ( 2, 3 ). Although the mechanism of cisplatin sensitization to IR remains largely undefined, evidence suggests that the NHEJ pathway is involved ( 4, 5 ). graph with multiple edgesWebCisplatin is a chemotherapy drug that contains the metal platinum. It stops or slows growth of cancer cells and other cells that grow rapidly by damaging their DNA. FDA Approved … chit chat crackersWebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … chitchat definitionWebCisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Synonym … chit-chat definitionWebIntroduction: The aim of this multicenter phase II trial was to evaluate the combination of oral vinorelbine and cisplatin with radiotherapy (RT) after cisplatin-docetaxel induction chemotherapy (CT) in patients with locally advanced non-small cell lung cancer (NSCLC). Patients and methods: Patients with previously untreated, inoperable, histologically or … graph with minimum and maximumWebApr 13, 2024 · The chances of cure with this type of chemotherapy are exceptionally high for testicular cancer. However, in some patients the tumor develops cisplatin resistance, which is associated with a reduced survival rate. To get to the bottom of the causes of cisplatin resistance in testicular cancer, the Bonn research team used CRISPR gene scissors. graph with multiplicity of 2